Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Nakimuli-Mpungu, E. Articles by Katabira, E. Search for Related Content PubMed Citation Articles by Nakimuli-Mpungu, E. Articles by Katabira, E. AIDS/HIV Bipolar Disorder Other Mood Disorders Syndromes Secondary to General Medical Disorders Related Articles

Primary Mania Versus HIV-Related Secondary Mania in Uganda

OBJECTIVE: The authors hypothesized that in the majority of HIV-positive patients presenting with mania, the mania is secondary to HIV infection and that its presentation and correlates differ from those of HIV-negative patients with primary mania. METHOD: A comparative cross-sectional study was conducted with HIV-negative and HIV-positive patients admitted to psychiatric wards with acute mania. The authors compared the patients’ psychiatric, physical, and immunological (CD4 cell counts) and other laboratory parameters. Pairwise comparisons were done for the two groups on a number of variables. RESULTS: Of 141 patients who presented with acute mania during a 6-month period and were eligible for the study, 61 met criteria for HIV-related secondary mania. Compared with HIV-negative patients with primary mania, they were older, more cognitively impaired less educated, and more likely to be female. Patients in this group had more manic symptoms: they were more irritable, more aggressive, more talkative, and had higher rates of paranoid delusions, visual hallucinations, and auditory hallucinations. More of the HIV-positive secondary mania group had CD4 counts below 350 cells/mm³. CONCLUSIONS: Primary mania and HIV-related secondary mania are clinically and immunologically distinct. The relation between secondary mania and depressed CD4 counts suggests that in the setting of an HIV/AIDS epidemic in poor countries, secondary mania may be used as an indicator to initiate highly active antiretroviral therapy.

Related Articles:

Primary Mania Versus Secondary Mania of HIV/AIDS in Uganda

Robert G. Robinson
Am J Psychiatry 2006 163: 1309-1311. [Full Text] [PDF]

This article has been cited by other articles:

				J. D. Maggi and M. H. Halman The Effect of Divalproex Sodium on HIV Replication In Vivo J Neuropsychiatry Clin Neurosci, August 1, 2007; 19(3): 326 - 330. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2006 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us