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Comparison of Cortical 5-HT_2A Receptor Binding in Bulimia Nervosa Patients and Healthy Volunteers

OBJECTIVE: Bulimia nervosa has been associated with alterations in central serotonergic (5-HT) function. This study investigated iodine-labeled 4-amino-N-[1-[3-(4-fluorophenoxy) propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (¹²³I-5-I-R91150) binding to the 5-HT_2A receptor in the brain by using single photon emission computed tomography in acutely ill bulimia nervosa patients. METHOD: Cortical ¹²³I-5-I-R91150 binding in 10 normal-weight patients with bulimia nervosa, purging type, was compared with that of 11 healthy volunteers. RESULTS: The 5-HT_2A binding index of the bulimia nervosa patients, with and without correction for age, was not significantly different from that of the comparison group. CONCLUSIONS: As a group, acutely ill bulimia nervosa patients cannot be discriminated from healthy subjects on the basis of cortical ¹²³I-5-I-R91150 binding to the 5-HT_2A receptor.

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				A. M. Catafau, M. Danus, S. Bullich, J. Llop, J. Perich, V. J. Cunningham, P. Plaza, M. M. Penengo, J. L.H. Eersels, L. Squassante, et al. Characterization of the SPECT 5-HT2A Receptor Ligand 123I-R91150 in Healthy Volunteers: Part 1--Pseudoequilibrium Interval and Quantification Methods J. Nucl. Med., June 1, 2006; 47(6): 919 - 928. [Abstract] [Full Text] [PDF]

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