Am J Psychiatry 155:768-773, June 1998
© 1998 American Psychiatric Association
Sex Differences in the Striatal Dopamine D2 Receptor Binding Characteristics in Vivo
Tiina Pohjalainen, M.Sc.,
Juha O. Rinne, M.D.,
Kjell Någren, Ph.D.,
Erkka SyvÄlahti, M.D., and
Jarmo Hietala, M.D.
OBJECTIVE: The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in D2 receptor density due to aging. METHOD: Striatal D2 receptor density (Bmax), affinity (Kd), and binding potential (Bmax/Kd) were measured with positron emission tomography and [11C]raclopride in 54 healthy subjects (33 men and 21 women). RESULTS: Women had generally lower D2 receptor affinity than men, and this difference was statistically significant in the left striatum. Bmax and Bmax/Kd tended to decline with age twice as fast in men as in women, but the difference did not reach statistical significance. CONCLUSIONS: These results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo. The lower D2 receptor affinity suggests an increased endogenous striatal dopamine concentration in women. This may have implications for the differential vulnerability of men and women to psychiatric disorders like schizophrenia and alcohol and substance dependence.
This article has been cited by other articles:
|
|
|
|
 
C. A Haaxma, B. R Bloem, G. F Borm, W. J G Oyen, K. L Leenders, S. Eshuis, J. Booij, D. E Dluzen, and M. W I M Horstink
Gender differences in Parkinson's disease
J. Neurol. Neurosurg. Psychiatry,
August 1, 2007;
78(8):
819 - 824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Yacubian, T. Sommer, K. Schroeder, J. Glascher, R. Kalisch, B. Leuenberger, D. F. Braus, and C. Buchel
Gene gene interaction associated with neural reward sensitivity
PNAS,
May 8, 2007;
104(19):
8125 - 8130.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Koch, O. Pogarell, G. Popperl, J. Hornung, C. Hamann, F.-J. Gildehaus, K. Seelos, D. Lewis, A. Favit, and K. Tatsch
Extended Studies of the Striatal Uptake of 99mTc-NC100697 in Healthy Volunteers
J. Nucl. Med.,
January 1, 2007;
48(1):
27 - 34.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Riccardi, D. Zald, R. Li, S. Park, M. S. Ansari, B. Dawant, S. Anderson, N. Woodward, D. Schmidt, R. Baldwin, et al.
Sex Differences in Amphetamine-Induced Displacement of [18F]Fallypride in Striatal and Extrastriatal Regions: A PET Study
Am J Psychiatry,
September 1, 2006;
163(9):
1639 - 1641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Brody, R. E. Olmstead, E. D. London, J. Farahi, J. H. Meyer, P. Grossman, G. S. Lee, J. Huang, E. L. Hahn, and M. A. Mandelkern
Smoking-Induced Ventral Striatum Dopamine Release
Am J Psychiatry,
July 1, 2004;
161(7):
1211 - 1218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Karim and A. Burns
The Biology of Psychosis in Older People
J Geriatr Psychiatry Neurol,
December 1, 2003;
16(4):
207 - 212.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L. N. Yatham, P. F. Liddle, R. W. Lam, I-S. Shiah, C. Lane, A. J. Stoessl, V. Sossi, and T. J. Ruth
PET Study of the Effects of Valproate on Dopamine D2 Receptors in Neuroleptic- and Mood-Stabilizer-Naive Patients With Nonpsychotic Mania
Am J Psychiatry,
October 1, 2002;
159(10):
1718 - 1723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Harper Mozley, R. C. Gur, P. D. Mozley, and R. E. Gur
Striatal Dopamine Transporters and Cognitive Functioning in Healthy Men and Women
Am J Psychiatry,
September 1, 2001;
158(9):
1492 - 1499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Kaasinen, K. Någren, J. Hietala, L. Farde, and J. O. Rinne
Sex Differences in Extrastriatal Dopamine D2-Like Receptors in the Human Brain
Am J Psychiatry,
February 1, 2001;
158(2):
308 - 311.
[Abstract]
[Full Text]
|
|
|
Get information about faster international access.
Privacy Policy
Copyright © 1998
American Psychiatric Association.
All rights reserved.
Home
| Search
| Current Issue
| Past Issues
| Subscribe
| All APPI Journals
| Help
| Contact Us
|
