Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Maixner, S. Articles by Shipley, J. Search for Related Content PubMed Citation Articles by Maixner, S. Articles by Shipley, J. Schizophrenia Spectrum Disorders Sleep Disorders

Effects of Antipsychotic Treatment on Polysomnographic Measures in Schizophrenia: A Replication and Extension

Objective:The authors sought to replicate and extend previous observations of improvement in some EEG sleep measures during the course of antipsychotic treatment in schizophrenia patients. Method:Fourteen medication-free patients with schizophrenia underwent 2 nights of sleep EEG monitoring before and after 3–4 weeks of treatment with clinically determined doses of haloperidol or thiothixene.Results:Measures of sleep continuity improved consistently. REM latency increased, although five of 14 patients continued to exhibit short REM latencies (less than 60 minutes). Stage 3 sleep increased during neuroleptic treatment, while stage 4 sleep did not change.Conclusions:These data demonstrate partial improvement of some but not all EEG sleep measures in schizophrenic patients through the course of neuroleptic treatment. They suggest that shortened REM latency and disturbed sleep continuity might represent reversible state abnormalities, while reduced slow-wave sleep may represent a more persistent trait abnormality in schizophrenia. Am J Psychiatry 1998; 155: 1600-1602

This article has been cited by other articles:

				H. Yamashita, K. Mori, M. Nagao, Y. Okamoto, S. Morinobu, and S. Yamawaki Influence of Aging on the Improvement of Subjective Sleep Quality by Atypical Antipsychotic Drugs in Patients With Schizophrenia: Comparison of Middle-Aged and Older Adults Am J Geriatr Psychiatry, May 1, 2005; 13(5): 377 - 384. [Abstract] [Full Text] [PDF]

				T. J. Raedler, M. B. Knable, D. W. Jones, R. A. Urbina, J. G. Gorey, K. S. Lee, M. F. Egan, R. Coppola, and D. R. Weinberger In Vivo Determination of Muscarinic Acetylcholine Receptor Availability in Schizophrenia Am J Psychiatry, January 1, 2003; 160(1): 118 - 127. [Abstract] [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 1998 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us