Am J Psychiatry 1993; 150:1726-1727
Copyright © 1993 by American Psychiatric Association
Alzheimer's-disease-related protein in geriatric schizophrenic patients with cognitive impairment
P Powchik, M Davidson, CB Nemeroff, V Haroutunian, D Purohit, M Losonczy, G Bissette, D Perl, H Ghanbari and B Miller
Department of Psychiatry, Mount Sinai Medical Center, New York.
The authors compared Alz-50 immunoreactivity in the brain tissue of nine
cognitively impaired elderly schizophrenic patients and 13 elderly
comparison subjects, both without neuritic plaques or neurofibrillary
tangles, and 13 patients with Alzheimer's disease. Alz-50 reactivity was
absent in the schizophrenic patients, indicating that geriatric,
cognitively impaired patients are unlikely to display the pathology of
Alzheimer's disease.
