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Am J Psychiatry 1992; 149:924-930
Copyright © 1992 by American Psychiatric Association
Regional cerebral blood flow in childhood autism: a SPECT study
M Zilbovicius, B Garreau, N Tzourio, B Mazoyer, B Bruck, JL Martinot, C Raynaud, Y Samson, A Syrota and G Lelord
Service Hospitalier Frederic Joliot, Direction des Sciences du Vivant, Orsay, France.
OBJECTIVE: The authors investigated a possible cortical brain dysfunction
associated with infantile autism. METHOD: They measured regional cerebral
blood flow with single photon emission computed tomography (SPECT) and
xenon-133 in 21 children with primary autism (according to DSM-III-R
criteria). Five cortical brain areas including frontal, temporal, and
sensory association cortices were examined in order to test the recent
hypothesis of cerebral dysfunction in primary autism. Anatomical references
for each subject were obtained with computerized tomography or magnetic
resonance imaging and were used to delimit the regions of interest for
SPECT analysis. RESULTS: When the results from the group with primary
autism were compared with an age- matched group of nonautistic children
with slight to moderate language disorders (N = 14), no cortical regional
abnormalities were found. CONCLUSIONS: It appears that there is no regional
cortical dysfunction in primary autism; however, in light of methodological
limitations, one cannot exclude the possibility of more localized or
subcortical brain dysfunctions in autism.
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