Am J Psychiatry 1989; 146:1611-1613
Copyright © 1989 by American Psychiatric Association
Increase in desipramine serum levels associated with methadone treatment
I Maany, V Dhopesh, IO Arndt, W Burke, G Woody and CP O'Brien
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
Five men in a methadone treatment program who were also receiving
desipramine had significantly higher desipramine serum levels when taking
both drugs than when taking the antidepressant alone. Monitoring of
desipramine serum levels may be useful with such patients.