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Am J Psychiatry 1988; 145:1015-1017
Copyright © 1988 by American Psychiatric Association

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Serotonergic and noradrenergic sensitivity in obsessive-compulsive disorder: behavioral findings

E Hollander, M Fay, B Cohen, R Campeas, JM Gorman and MR Liebowitz
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032.

Six of eight patients with obsessive-compulsive disorder had an exacerbation of symptoms when given m-chlorophenylpiperazine. Fenfluramine and placebo produced mild improvement. Six patients given intravenous clonidine experienced marked reduction in obsessions. Implications for serotonergic and noradrenergic hypotheses of obsessive- compulsive disorder are discussed.




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