Am J Psychiatry 1988; 145:878-879
Copyright © 1988 by American Psychiatric Association
Exacerbation of psychosis after discontinuation of carbamazepine treatment
CW Heh, J Sramek, J Herrera and J Costa
Clinical Research Unit, Metropolitan State Hospital, Norwalk, Calif.
Carbamazepine alone or carbamazepine plus neuroleptic was administered to
20 chronic schizophrenic patients. Upon abrupt discontinuation two of the
20 patients had exacerbations of their psychoses characterized by paranoia,
hostility, and agitation. The authors discuss the possibility of a
carbamazepine withdrawal syndrome.
