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Am J Psychiatry 1985; 142:1373-1374
Copyright © 1985 by American Psychiatric Association

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Pharmacokinetic interaction of disulfiram and antidepressants

DA Ciraulo, J Barnhill and H Boxenbaum

Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.




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