Am J Psychiatry 1981; 138:1235-1237
Copyright © 1981 by American Psychiatric Association
Concentrations of desipramine in elderly women
NR Cutler, AP Zavadil 3d, C Eisdorfer, RJ Ross and WZ Potter
Seven elderly depressed women were given desipramine, and plasma
concentrations of the drug were measured from blood samples drawn after a
single dose and during long-term use. The concentrations were no different
from those found in younger patients. Aging does not seem to alter the
plasma concentration of desipramine, and the authors conclude that the
increased incidence and severity of the drug's side effects are probably
not due to high drug concentrations.
