Am J Psychiatry 1976; 133:197-202
Copyright © 1976 by American Psychiatric Association
The dopamine hypothesis of schizophrenia: focus on the dopamine receptor
SH Snyder
Alleviation of schizophrenic symptoms by phenothiazines and butyrophenones
is associated with blockade of dopamine receptors, while exacerbation of
symptoms by amphetamines appears to result from enhanced synaptic activity
of dopamine and/or norepinephrine. The author suggests that biochemical
labeling of the dopamine receptor with 3H-dopamine and 3H-haloperidol may
clarify mechanisms of drug effects on the dopamine receptor.
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